Tumor-associated macrophages promote human hepatoma Huh-7 cell migration and invasion through the Gli2/IGF-II/ERK1/2 axis by secreting TGF- β1.

CONCLUSION: The TGF-β1 secreted by TAMs promotes the migration, invasion and EMT of human hepatoma Huh-7 cells through the Gli2/IGF-II/ERK1/2 pathway.
PMID: 33081566 [PubMed - as supplied by publisher]

Source: Cancer Biology and Therapy - October 21, 2020 Category: Cancer & Oncology Authors: Liu M, Zhong YB, Shao J, Zhang C, Shi C Tags: Cancer Biol Ther Source Type: research