Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes.

This study provides support for selective HDAC/BRD4 dual inhibitors as epigenetic probes based on pyrrolopyridone core for the future biological evaluation in different cancer cell lines.
PMID: 33077265 [PubMed - as supplied by publisher]

Source: European Journal of Medicinal Chemistry - October 13, 2020 Category: Chemistry Authors: Chen J, Li Y, Zhang J, Zhang M, Wei A, Liu H, Xie Z, Ren W, Duan W, Zhang Z, Shen A, Hu Y Tags: Eur J Med Chem Source Type: research