Nerve growth factor sensitizes nociceptors to C ‐fiber selective
ConclusionsNGF ‐induced sensitization of human skin to electrical and mechanical stimuli is primarily driven by C‐nociceptors with little contribution from A‐delta fibers. Less pronounced accommodation during ongoing sinusoidal stimulation suggests that NGF could facilitate axonal spike generation and conduc tion in primary afferent nociceptors in humans. Further studies using this sinusoidal electrical stimulation profile to investigate patients with chronic inflammatory pain may allow localized assessment of skin C‐nociceptors and their putative excitability changes under pathologic conditions.
Source: European Journal of Pain - Category: Anesthesiology Authors: Mark Schnakenberg,
Christian Thomas,
Martin Schmelz,
Roman Rukwied Tags: ORIGINAL ARTICLE Source Type: research