Over-Expression of Immune-Related lncRNAs in Inflammatory Demyelinating Polyradiculoneuropathies

AbstractLong non-coding RNAs (lncRNAs) have crucial roles in the pathogenesis of immune-related disorders. However, their role in the pathobiology of inflammatory demyelinating polyradiculoneuropathies remains unclear. In the current study, we measured peripheral expression of four lncRNAs, namelyTUG1,FAS-AS1,NEAT1, andGAS5, in patients with acute/chronic inflammatory demyelinating polyradiculoneuropathies (AIDP/CIDP) compared with healthy subjects. Notably, all lncRNAs were over-expressed in patients compared with controls (P< 0.0001 for all lncRNAs). When assessing their expressions in AIDP and CIDP groups separately,TUG1 andNEAT1 were up-regulated in both patient groups compared with controls, yetFAS-AS1 andGAS5 were only up-regulated in CIDP cases. There were remarkable pairwise correlations between expression levels of these lncRNAs in all study groups. Based on the above-mentioned data, we suggest participation of these for lncRNAs in the pathogenesis of inflammatory demyelinating polyradiculoneuropathies. Moreover,FAS-AS1 andGAS5 lncRNAs have type-specific roles in this regard. Future functional studies are needed to elaborate the molecular mechanisms of the contribution of these transcripts in AIDP/CIDP.

Source: Journal of Molecular Neuroscience - October 15, 2020 Category: Neuroscience Source Type: research