Matrix metalloproteinases deregulation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons that results in progressive paralysis and muscular atrophy. There are many molecules and genes involved in neuromuscular degeneration in ALS; among these, matrix metalloproteinases (MMPs). MMPs play an important role in the pathology of ALS, and MMP-1, 2, 3, and 9 might serve as disease progression markers. Tissue inhibitors of metalloproteinases (TIMPS) might also function as progression markers in ALS because they participate in regulating the proteolytic activity of MMPs.

Source: Journal of the Neurological Sciences - October 11, 2020 Category: Neurology Authors: Jorge Luis S ánchez-Torres, Petra Yescas Gómez, Julio Torres-Romero, Oscar Rojas Espinosa, Lilia López Canovas, Ángeles C. Tecalco-Cruz, María Dolores Ponce-Regalado, María Elizbeth Álvarez Sánchez Tags: Review Article Source Type: research