Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs.

Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs. World J Hepatol. 2020 Sep 27;12(9):574-595 Authors: Philips CA, Ahamed R, Rajesh S, George T, Mohanan M, Augustine P Abstract With growing antipathy toward conventional prescription drugs due to the fear of adverse events, the general and patient populations have been increasingly using complementary and alternative medications (CAMs) for managing acute and chronic diseases. The general misconception is that natural herbal-based preparations are devoid of toxicity, and hence short- and long-term use remain justified among people as well as the CAM practitioners who prescribe these medicines. In this regard, Ayurvedic herbal medications have become one of the most utilized in the East, specifically the Indian sub-continent, with increasing use in the West. Recent well-performed observational studies have confirmed the hepatotoxic potential of Ayurvedic drugs. Toxicity stems from direct effects or from indirect effects through herbal metabolites, unknown herb-herb and herb-drug interactions, adulteration of Ayurvedic drugs with other prescription medicines, and contamination due to poor manufacturing practices. In this exhaustive review, we present details on their hepatotoxic potential, discuss the mechanisms, clinical presentation, liver histology and patient outcomes of certain commonly used Ayurvedic herbs which will serve as a knowledge bank for physicians caring...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research

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Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
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Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
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Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
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Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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Source: Hepatology International - Category: Infectious Diseases Source Type: research
Publication date: Available online 9 October 2020Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Si-Yu Shao, Yi-Lan Wang, Li-Min Feng, Ying Zhao
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
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