Localization of goose hemorrhagic polyomavirus in naturally infected geese using in situ hybridization.

Localization of goose hemorrhagic polyomavirus in naturally infected geese using in situ hybridization. Avian Pathol. 2020 Oct 06;:1-32 Authors: Tu YC, Li WT, Lee F, Huang CW, Chang JC, Hsu WC, Hu SC, Chiou CJ, Chen YP Abstract Goose hemorrhagic polyomavirus (GHPV) is the etiological agent of hemorrhagic nephritis enteritis of geese (HNEG), a fatal disease that impacts geese and has been recorded only in Europe. The present study describes the first clinical cases of HNEG in Taiwan and the phylogenesis of Taiwanese GHPV, and it elucidates the pathogenesis of GHPV infection using in situ hybridization (ISH). The genomes of Taiwanese GHPV were highly similar to the previously reported strains. The diseased geese showed various degrees of vascular damage, especially in the digestive tract. The affected geese in the early stage showed transmural hemorrhagic enteritis in the intestine. In the middle to late stages, the most obvious lesion was hypoxic necrosis of renal tubules around intralobular central veins. Mineralization deposited in the kidney and systemic gout were also found. ISH revealed GHPV DNA in the vascular endothelial cells throughout the body, but not in the parenchymal cells of organs. Accordingly, the pathogenesis of GHPV infection was consistent with viral tropism in the endothelial cells. Specific attack to vascular endothelium by GHPV resulted in endothelial cell necrosis and subsequent increases of blood vessel permeability, as well as a ...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research

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Authors: Mosquera J, Pedreañez A Abstract Increasing evidence supports a central role of the immune system in acute post streptococcal glomerulonephritis (APSGN), but the current view of how streptococcal biology affects immunity, and vice versa, remains to be clarified. Renal glomerular immune complex deposition is critical in the initiation of APSGN; however, mechanisms previous to immune complex formation could modulate the initiation and the progression of the disease. Initial and late renal events involved in the nephritis can also be related to host factors and streptococcal factors. In this review we ...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
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Source: Histochemistry and Cell Biology - Category: Biomedical Science Source Type: research
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Source: Neurological Sciences - Category: Neurology Source Type: research
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Source: Quintessence International - Category: Dentistry Source Type: research
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Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
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Source: Journal of the Taiwan Institute of Chemical Engineers - Category: Chemistry Source Type: research
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