Does general anesthesia increase dementia risk?

(Wiley) There are concerns that exposure to general anesthesia during surgery may contribute to an increased risk of Alzheimer's disease. To investigate, researchers compared exposure to general anesthesia versus regional anesthesia during elective surgery, looking for potential links to the development of dementia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

Related Links:

Abstract There is a strong unmet need for translational progress towards Alzheimer's disease (AD) modifying therapy. Unfortunately, preclinical modeling of the disease has been disappointing, relying primarily on transgenic mouse overexpression of rare dominant mutations. Clinical manifestation of AD symptoms is known to reflect interaction between environmental and genetic risks. Mild traumatic brain injury (mTBI) is an environmental risk for dementia, including Alzheimer's, but there has been limited mechanistic analysis of mTBI contribution to AD. Here, we investigate the interplay between mTBI and Aβ prec...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
Intra-gastrointestinal amyloid-β1-42 oligomers perturb enteric function and induce Alzheimer's disease pathology. J Physiol. 2020 Jul 02;: Authors: Sun Y, Sommerville NR, Liu JYH, Ngan MP, Poon D, Ponomarev ED, Lu Z, Kung JSC, Rudd JA Abstract KEY POINTS: Alzheimer's disease (AD) patients and transgenic mice have beta-amyloid (Aβ) aggregation in the gastrointestinal (GI) tract. It is possible that Aβ from the periphery contributes to the load of Aβ in the brain, as Aβ has prion-like properties. The present investigations demonstrate that Aβ injected into the GI tract of I...
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
Background Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve cognitive function. The authors therefore tested the primary hypothesis that preoperative use of angiotensin inhibitors is associated with less delirium in critical care patients.Post hoc, the association between postoperative use of angiotensin system inhibitors and delirium was assessed.Methods The authors conducted a single-site cohort study of adults admitted to Cleveland Clinic critical care units after noncardiac procedures between 2013 and 2018 who had at least one Confusion Assessment Method delirium assessment. Patients w...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Conclusions: Although mGluR2 and mGluR5 have different synaptic location and functional mechanism both [11C]mG2P001 and [18F]FPEB showed significantly decreased radioactivity in their specific receptor binding regions in AD mice model compared to that of the control group. The MWM behavior test further indicated the reduced hippocampal radioactivity attributed to the observed cognitive/memory impairment among AD mice, where 19.3% and 34.3% radioactivity decrease were seen for [11C]mG2P001 and [18F]FPEB in hippocampus, respectively. In addition, the aberrant changes of [11C]mG2P001 in subiculum, where the first accumulation...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research
Conclusions The results do not support an association between surgical hospitalization and elevated brain amyloid.Editor ’s PerspectiveWhat We Already Know about This TopicHospitalization for medical illness and surgical procedures has been associated with subsequent cognitive decline in some older patientsAnimal models have suggested that surgery and anesthesia may lead to an increased production and accumulation of brain amyloidWhat This Article Tells Us That Is NewThis study found no differences in brain amyloid levels measured by positron emission tomography scans more than a decade after hospitalization for a su...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Authors: Wang P, Velagapudi R, Kong C, Rodriguiz RM, Wetsel WC, Yang T, Berger M, Gelbard HA, Colton CA, Terrando N Abstract OBJECTIVE: The present work evaluates the relationship between postoperative immune and neurovascular changes and the pathogenesis of surgery-induced delirium superimposed on dementia. BACKGROUND AND RATIONALE: Postoperative delirium is a common complication in many older adults and in patients with dementia including Alzheimer's disease (AD). The course of delirium can be particularly debilitating, while its pathophysiology remains poorly defined. HISTORICAL EVOLUTION: As of 2019, an...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
You're reading How Does Sleeping Well Impact Brain Detoxification?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Have you been sleeping well lately? We all know that getting enough sleep is an important part of living a healthy and engaged life. Of course, getting a good night's sleep keeps you sharp during the day, and recent science has also shown how important it is in learning and memory. Sleep is not only good for helping you pay attention in class or remembering what you did yesterday though, it also helps keep ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement better sleep brain health science of sleep Source Type: blogs
Abstract Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which seriously threatens the quality of patients' life, especially the older people. Accumulating attention has been paid to POCD worldwide in pace with the popularization of anesthesia/surgery. The development of medical humanities and rehabilitation medicine sets higher demands on accurate diagnosis and safe treatment system of POCD. Although the research on POCD is in full swing, underlying pathogenesis is still inconclusive due to these conflicting results and controversial evidence. Generally, POCD is closely related ...
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research
What exactly is psychosis? What happens in the brain of a person with schizophrenia who is hallucinating? Schizophrenic Rachel Star Withers shares her personal hallucinations and delusions and Dr. Joseph Goldberg, who specializes in researching what goes on in the brain when someone is experiencing psychosis, joins to break down how the brain functions during psychotic episodes. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects in this episode of Inside Schizophrenia.  Highlights from “Psychosis in Schizophrenia” Episode [02:13]  Rachel, do...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
More News: Alzheimer's | Anesthesia | Anesthesiology | Dementia | International Medicine & Public Health