Challenges Associated With Neuropharmacological Challenge Studies

In the current issue of Biological Psychiatry, Strube et  al. (1) present a large-scale neuropharmacological challenge study in healthy individuals testing two candidate neurotransmitter–neuroreceptor mechanisms posited to underlie probabilistic reasoning deficits in actively psychotic schizophrenia patients: 1) deficient glutamatergic NMDA receptor (N MDAR) neurotransmission and 2) excessive dopaminergic D2 receptor (D2R) neurotransmission. Research on delusions in schizophrenia has implicated impairments in probabilistic reasoning.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research