A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis

Conclusion: Our study uncovers a GEF-independent role of ECT2 in promoting survival of breast cancer cells, provides a molecular insight for the reciprocal regulation of ECT2 and USP7, and supports the pursuit of ECT2/USP7 as potential targets for breast cancer intervention.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Qi Zhang, Cheng Cao, Wenchen Gong, Kaiwen Bao, Qian Wang, Yuejiao Wang, Liyuan Bi, Shuai Ma, Jiao Zhao, Ling Liu, Shanshan Tian, Kai Zhang, Jie Yang, Zhi Yao, Nan Song, Lei Shi Tags: Research Paper Source Type: research