Viral RNA detection by RIG-I-like receptors.

Viral RNA detection by RIG-I-like receptors.
Curr Opin Immunol. 2015 Jan 13;32C:48-53
Authors: Yoneyama M, Onomoto K, Jogi M, Akaboshi T, Fujita T
Abstract
In higher vertebrates, recognition of the non-self signature of invading viruses by genome-encoded pattern recognition receptors initiates antiviral innate immunity. Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) detect viral RNA as a non-self pattern in the cytoplasm and activate downstream signaling. Detection of viral RNA also activates stress responses resulting in stress granule-like aggregates, which facilitate RLR-mediated antiviral immunity. Among the three RLR family members RIG-I and melanoma differentiation-associated gene 5 (MDA5) recognize distinct viral RNA species with differential molecular machinery and activate signaling through mitochondrial antiviral signaling (MAVS, also known as IPS-1/VISA/Cardif), which leads to the expression of cytokines including type I and III interferons (IFNs) to restrict viral propagation. In this review, we summarize recent knowledge regarding RNA recognition and signal transduction by RLRs and MAVS/IPS-1.
PMID: 25594890 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - January 13, 2015 Category: Allergy & Immunology Authors: Yoneyama M, Onomoto K, Jogi M, Akaboshi T, Fujita T Tags: Curr Opin Immunol Source Type: research