Factors predisposing to thrombosis after major joint arthroplasty.
CONCLUSION: Screening of coagulation profile, instead of platelet monitoring, is probably the safest way to minimize the risk of post-arthroplasty thrombosis. In addition, fondaparinux can lead to the formation of anti-PF4/heparin antibodies or HIT. PMID: 32999860 [PubMed]
Conditions: Acute Leukemia; Deep Vein Thrombosis; Hematopoietic and Lymphoid Cell Neoplasm; Hodgkin Lymphoma; Myeloproliferative Neoplasm; Non-Hodgkin Lymphoma; Plasma Cell Myeloma; Thrombocytopenia Interventions: Procedure: Biospecimen Collection; Other: Electronic Health Record Review Sponsors: Mayo Clinic; National Cancer Institute (NCI) Recruiting
Condition: Osteoarthritis, Knee Interventions: Drug: Ropivacaine Continuous Infusion; Drug: Ropivacaine Intermittent Bolus; Drug: Placebo Sponsor: Mayo Clinic Not yet recruiting
Condition: Hip Osteoarthritis Intervention: Device: SL-PLUS-Stem for total hip arthroplasty Sponsors: Kantonsspital Baselland Bruderholz; Smith & Nephew, Inc. Completed
Condition: Osteoarthritis, Knee Interventions: Other: compressive myofascial release; Other: conventional treatment group Sponsor: Riphah International University Completed
CONCLUSION: In brief RT inhibited AGE-induced inflammatory reaction and also degradation of ECM via targeting the NF-κB/MAPK pathway proteins BCL-2 and TRAF-6. RT can be a potential molecule in treating OA.PMID:34550907 | DOI:10.18632/aging.203470
CONCLUSION: Australian physical therapists treating knee osteoarthritis typically provide strength-based home exercise with written instructions, alongside goal setting and physical activity advice. Just one in nine could name a guideline. Education and training activities are needed to support physical therapists to access, read and implement guidelines, especially for aerobic and neuromuscular exercise, and weight management.PMID:34548210 | DOI:10.1016/j.bjpt.2021.08.001
Mol Med Rep. 2021 Nov;24(5):813. doi: 10.3892/mmr.2021.12453. Epub 2021 Sep 22.ABSTRACTOsteoarthritis (OA) is one of the most prevalent pain‑inducing and disabling diseases globally. Aging is a primary contributing factor to the progression of OA. Forkhead box protein O4 (FOXO4) is known to be involved in the cell cycle and apoptosis regulation. The aim of the present study was to investigate the association between FOXO4 expression and chondrocyte degeneration in rats. Chondrocytes were assigned to the control (4‑week‑old rats), natural degeneration (16‑week‑old rats) or induced degeneration (IL‑1β‑trea...
NEW YORK (Reuters Health)—Lower doses of cannabidiol (CBD) failed to provide any meaningful reduction in pain when added to other analgesic therapy in patients with hand osteoarthritis (OA) or psoriatic arthritis (PsA) in a randomized, placebo-controlled study from Denmark.1 Writing in the journal, Pain, Jonathan Vela, MD, and colleagues of Aalborg University note that CBD... [Read More]
Molecules, Vol. 26, Pages 5732: Dual Delivery of TGF-β3 and Ghrelin in Microsphere/Hydrogel Systems for Cartilage Regeneration Molecules doi: 10.3390/molecules26195732 Authors: Jianjing Lin Li Wang Jianhao Lin Qiang Liu Articular cartilage (AC) damage is quite common, but due to AC’s poor self-healing ability, the damage can easily develop into osteoarthritis (OA). To solve this problem, we developed a microsphere/hydrogel system that provides two growth factors that promote cartilage repair: transforming growth factor-β3 (TGF-β3) to enhance cartilage tissue formation and ghrelin synergy ...