Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD)

Post-transplant lymphoproliferative disorders are comprised of lymphoid or plasmacytic proliferations that develop because of immunosuppression following solid organ, bone marrow, or stem cell allotransplant 1 2 . Vast majority of PTLDs are associated with the EBV infection and constitute EBV-driven polyclonal or monoclonal B-cell or T-cell proliferations 3. There are four major subtypes of PTLDs (according to WHO 2016) – non-destructive PTLDs, monomorphic, polymorphic and classic Hodgkin lymphoma.

Source: Cancer Genetics and Cytogenetics - October 1, 2020 Category: Genetics & Stem Cells Authors: Anna Shestakova, Narina Grove, Jonathan Said, Sophie Song, Fabiola Quintero-Rivera Source Type: research