Internalization of HMGB1 (High Mobility Group Box 1) Promotes Angiogenesis in Endothelial Cells.

CONCLUSIONS: In this study, we identified a novel pathway of HMGB1 internalization-induced angiogenesis in endothelial cells. This finding sheds light on the regulatory role of inflammatory factors in angiogenesis through cell internalization and opens a new door to understand the relationship between inflammation and angiogenesis in ischemic diseases.
PMID: 32998518 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 30, 2020 Category: Cardiology Authors: Lan J, Luo H, Wu R, Wang J, Zhou B, Zhang Y, Jiang Y, Xu J Tags: Arterioscler Thromb Vasc Biol Source Type: research