Association of Anti –Topoisomerase I Antibodies of the IgM Isotype With Disease Progression in Anti–Topoisomerase I–Positive Systemic Sclerosis

ConclusionIn SSc patients who were anti –topo I IgG–positive, presence of anti–topo I IgM, which might be considered as a surrogate for an ongoing autoreactive B cell immune response, is associated with disease progression.

Source: Arthritis and Rheumatology - September 28, 2020 Category: Rheumatology Authors: Maaike Boonstra, Jaap A. Bakker, Annette Grummels, Maarten K. Ninaber, Nina Ajmone Marsan, Corrie M. Wortel, Tom W. J. Huizinga, Suzana Jordan, Anna ‐Maria Hoffman‐Vold, Oliver Distler, René E. M. Toes, Hans Ulrich Scherer, Jeska K. Vries Tags: Original Article Source Type: research