Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM197 conjugate vaccine [Microbiology]

Polysaccharide-protein conjugates have been developed to overcome the T-independent response, hyporesponsiveness to repeated vaccination, and poor immunogenicity in infants of polysaccharides. To address the impact of polysaccharide length, typhoid conjugates made with short- and long-chain fractions of Vi polysaccharide with average sizes of 9.5, 22.8, 42.7, 82.0, and 165 kDa...

Source: Proceedings of the National Academy of Sciences - September 28, 2020 Category: Science Authors: Francesca Micoli, Stefania P. Bjarnarson, Melissa Arcuri, Audur Anna Aradottir Pind, Gudbjorg J. Magnusdottir, Francesca Necchi, Roberta Di Benedetto, Martina Carducci, Fabiola Schiavo, Carlo Giannelli, Ivan Pisoni, Laura B. Martin, Giuseppe Del Giudice, Tags: Biological Sciences Source Type: research