Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase pathways.

Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase pathways. Curr Neuropharmacol. 2020 Sep 24;: Authors: Siddiqui A, Akhtar MS, Shah Z, Othman I, Kumari Y Abstract It is a known fact that inflammation affects several physiological processes, including the functioning of the central nervous system. Additionally, impairment of lipid mechanisms/pathways have been associated with a number of neurodegenerative disorders and Alzheimer's Disease (AD) is one of them. However, much attention has been given to the link between tau and beta-amyloid hypothesis in AD pathogenesis/prognosis. Increasing evidences suggest that biologically active lipid molecules could influence the pathophysiology of AD via different mechanism of inflammation. In this review, we intend to highlight the role of inflammatory responses in the context of AD with the emphasis on biochemical pathways of lipid metabolism enzyme, 5-lipoxygenase (5-LO). PMID: 32972344 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research