Type 2 cytokines IL-4 and IL-5 reduce severe outcomes from Clostridiodes difficile infection.

This study tests the roles of two type 2 cytokines, IL-4 and IL-5, in mediating protection in a murine model of disease. Administration of IL-5 protected from mortality due to CDI, and both IL-4 and IL-5 were protective against severe disease symptoms. Together, the results from this study increase our understanding of how type 2 immune signaling processes are protective from severe C. difficile infection. PMID: 32971206 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32971206?dopt=Abstract

Source: Anaerobe - September 20, 2020 Category: Microbiology Authors: Donlan AN, Simpson ME, Petri WA Tags: Anaerobe Source Type: research