Autoantibodies directed against α1-adrenergic receptor and endothelin receptor A in patients with prostate cancer

ConclusionsWe hypothesized that α1-AAB and ETA-AAB, which are highly present in prostate cancer patients, could by their functional activity support carcinogenesis by excessive receptor stimulation. The in vitro demonstrated neutralization of α1- and ETA-AAB by the aptamer BC007 could open the door to complement the treatments a lready available for prostate cancer.
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research