Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies.

Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies.
Bioorg Med Chem Lett. 2020 Sep 19;:127559
Authors: McNulty J, Babu Dokuburra C, D'Aiuto L, Demers M, McClain L, Piazza P, Williamson K, Zheng W, Nimgaonkar VL
Abstract
The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.
PMID: 32961320 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry Letters - September 18, 2020 Category: Chemistry Authors: McNulty J, Babu Dokuburra C, D'Aiuto L, Demers M, McClain L, Piazza P, Williamson K, Zheng W, Nimgaonkar VL Tags: Bioorg Med Chem Lett Source Type: research