Molecules, Vol. 25, Pages 4381: Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice
Molecules, Vol. 25, Pages 4381: Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice
Molecules doi: 10.3390/molecules25194381
Authors:
Zakiyatul Faizah
Bella Amanda
Faisal Yusuf Ashari
Efta Triastuti
Rebecca Oxtoby
Anny Setijo Rahaju
M. Aminudin Aziz
Maria Inge Lusida
Delvac Oceandy
Diabetes mellitus (DM) is one of the major causes of death in the world. There are two types of DM—type 1 DM and type 2 DM. Type 1 DM can only be treated by insulin injection whereas type 2 DM is commonly treated using anti-hyperglycemic agents. Despite its effectiveness in controlling blood glucose level, this therapeutic approach is not able to reduce the decline in the number of functional pancreatic β cells. MST1 is a strong pro-apoptotic kinase that is expressed in pancreatic β cells. It induces β cell death and impairs insulin secretion. Recently, a potent and specific inhibitor for MST1, called XMU-MP-1, was identified and characterized. We hypothesized that treatment with XMU-MP-1 would produce beneficial effects by improving the survival and function of the pancreatic β cells. We used INS-1 cells and STZ-induced diabetic mice as in vitro and in vivo models to test the effect of XMU-MP-1 treatment. We found that XMU-MP-1 inhibited MST1/2 activity in INS-1 cells. Moreover, treatment with XMU-MP-1 produced a benefi...
Source: Molecules - Category: Chemistry Authors: Zakiyatul Faizah Bella Amanda Faisal Yusuf Ashari Efta Triastuti Rebecca Oxtoby Anny Setijo Rahaju M. Aminudin Aziz Maria Inge Lusida Delvac Oceandy Tags: Article Source Type: research
More News: Chemistry | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Endocrinology | Insulin | Pancreas | Study