Elucidating Epigenetic Regulation by Identifying Functional cis ‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage

ConclusionBy applying an improved detection strategy, robustly differentially expressed lncRNAs in OA cartilage were detected. Integration of these lncRNAs with differential mRNA expression levels in the same samples provided insight into their regulatory networks. Our data indicates that intergenic and antisense lncRNAs play an important role in regulating the pathophysiology of OA.

Source: Arthritis and Rheumatology - September 23, 2020 Category: Rheumatology Authors: Marcella Hoolwerff, Paula I. Metselaar, Margo Tuerlings, H. Eka D. Suchiman, Nico Lakenberg, Yolande F.M. Ramos, Davy Cats, Rob G.H.H. Nelissen, Demi ën Broekhuis, Hailiang Mei, Rodrigo Coutinho Almeida, Ingrid Meulenbelt Tags: Full Length Source Type: research