Ibrutinib Suppresses Early Megakaryopoiesis but Enhances Proplatelet Formation.

In conclusion, ibrutinib suppresses early megakaryopoiesis, as evidenced by inhibition of MK progenitor cell proliferation and CFU-MK formation. Ibrutinib enhances MK differentiation, ploidy, and proplatelet formation, while it impairs integrin αIIbβ3 outside-in signaling.
PMID: 32961571 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - September 21, 2020 Category: Hematology Authors: Huang J, Huang S, Ma Z, Lin X, Li X, Huang X, Wang J, Ye W, Li Y, He D, Yang M, Pan J, Ling Q, Li F, Mao S, Wang H, Wang Y, Jin J Tags: Thromb Haemost Source Type: research