Ecological and Evolutionary Challenges for Wildlife Vaccination.

Ecological and Evolutionary Challenges for Wildlife Vaccination.
Trends Parasitol. 2020 Sep 18;:
Authors: Barnett KM, Civitello DJ
Abstract
Wildlife vaccination is of urgent interest to reduce disease-induced extinction and zoonotic spillover events. However, several challenges complicate its application to wildlife. For example, vaccines rarely provide perfect immunity. While some protection may seem better than none, imperfect vaccination can present epidemiological, ecological, and evolutionary challenges. While anti-infection and antitransmission vaccines reduce parasite transmission, antidisease vaccines may undermine herd immunity, select for increased virulence, or promote spillover. These imperfections interact with ecological and logistical constraints that are magnified in wildlife, such as poor control and substantial trait variation within and among species. Ultimately, we recommend approaches such as trait-based vaccination, modeling tools, and methods to assess community- and ecosystem-level vaccine safety to address these concerns and bolster wildlife vaccination campaigns.
PMID: 32952060 [PubMed - as supplied by publisher]

Source: Trends in Parasitology - September 17, 2020 Category: Parasitology Authors: Barnett KM, Civitello DJ Tags: Trends Parasitol Source Type: research