QuantiFERON-TB Gold Plus with Chemiluminescence Immunoassay: Do We Need a Higher Cutoff? [Mycobacteriology and Aerobic Actinomycetes]
In conclusion, automated QFT-Plus with CLIA is comparable to QFT-Plus performed by ELISA. Within the linearity range of the test, CLIA detects higher quantitative values than ELISA, resulting in a higher number of determinate results and the conversion of samples that were close to the cutoff into positive borderline results. A higher cutoff for QFT-CLIA needs to be defined based on clinical diagnostic criteria.
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Bisognin, F., Lombardi, G., Re, M. C., Dal Monte, P. Tags: Mycobacteriology and Aerobic Actinomycetes Source Type: research