Online adaptive MR-guided radiotherapy for rectal cancer; feasibility of the workflow on a 1.5T MR-linac; clinical implementation and initial experience

Patients with intermediate or locally advanced rectal carcinoma are treated according to international guidelines with neoadjuvant radiotherapy with or without concurrent chemotherapy followed by total mesorectal excision surgery.[1,2] Neoadjuvant radiotherapy leads to a reduction in local recurrence rate but is still associated with substantial toxicity as large planning volumes are needed to compensate for inter- and intrafraction movement.[3,4] Particularly the mesorectum is a nonstationary structure, with large day-to-day variation as its shape and volume are affected by both bladder and rectal filling.

Source: Radiotherapy and Oncology - September 21, 2020 Category: Radiology Authors: M.P.W. Intven, S.R. de Mol van Otterloo, S. Mook, P.A.H. Doornaert, E.N. de Groot-van Breugel, G.G. Sikkes, M.E. Willemsen-Bosman, H.M. van Zijp, R.H.N. Tijssen Tags: Original Article Source Type: research