Hyperplastic candidiasis in a patient with acute lymphocytic leukemia: case report

Oral candidiasis is the most common fungal infection and one of its rarest forms is hyperplasia. It usually occurs in individuals with generalized immunosuppression and vitamin deficiency. This paper reports a case of a male patient, 3 years old, diagnosed with acute lymphocytic leukemia pre-B and undergoing chemotherapy for about a year. During the maintenance phase, he presented an exophytic, asymptomatic, pediculated, pale lesion, extending through the lingual dorsum. The chemotherapeutic treatment was interrupted to clarify the diagnosis after an incisional biopsy.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: 20190858 Source Type: research

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AbstractBackground Patients with haematological malignancies are at high risk of invasive fungal infections. However, there is a lack of information about the utilisation of the recommended Australian antifungal prophylaxis guidelines in haematology outpatients.Objective To assess the impact of a weekly pharmacist review of high-risk adult haematology outpatients on the utilisation of appropriate antifungal prophylaxis.Setting Outpatient cancer centre, tertiary referral hospital in Sydney, Australia.Method A 3-month pre-and post-interventional study was conducted. A retrospective audit was conducted to obtain baseline util...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
AbstractPurpose of ReviewIn the past 5  years, there has been a significant expansion in the oncology arsenal. These new oncolytic therapies are being incorporated with traditional cytotoxic chemotherapy or used as single-agent therapy. Disease states such as acute and chronic leukemias have seen some the largest therapy expansion in de cades. Frequently, these patients often necessitate the use of antifungals in either the prophylaxis or treatment setting. This review provides a brief overview of recently approved oncolytic therapies and the drug-drug interactions (DDIs) that clinicians encounter when managing antifu...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
The incidence and pattern of septicemia in this multicenter study in China was similar to reports of western countries. The septicemia related mortality rate was low. There was marked variation in the incidence of septicemia among the centers. AbstractBackgroundSepticemia is an important cause of treatment ‐related mortality and treatment failure in pediatric acute lymphoblastic leukemia (ALL) in developing countries. A multicenter CCCG‐ALL‐2015 study was conducted in China and factors associated with septicemia and mortality were studied.MethodsPatients participated in CCCG ‐ALL‐2015 study from January 2015 to D...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSION/DISCUSSION: Despite encouraging response rates and pharmacodynamics, the combination of decitabine and vorinostat on this intensive chemotherapy backbone was determined not feasible in B-ALL due to the high incidence of significant infectious toxicities. This study is registered at http://www.clinicaltrials.gov as NCT01483690. PMID: 31969338 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Acute leukemia is a group of aggressive malignant diseases, associated with a high degree of both morbidity and mortality. An important cause of both the latter is infectious complications. Patients with acute leukemia are highly susceptible to diseases both due to factors related to the disease itself, factors attributed to treatment and specific individual risk factors in each individual patient. Patients with chemotherapy induced neutropenia are at particularly high risk, and microbiological agents include viral, bacterial and fungal agents. The etiology is often unknown in infectious complications, although adequate pa...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Acute leukemias are a group of aggressive malignant diseases associated with a high degree of morbidity and mortality. An important cause of both the latter is infectious complications. Patients with acute leukemia are highly susceptible to infectious diseases due to factors related to the disease itself, factors attributed to treatment, and specific individual risk factors in each patient. Patients with chemotherapy-induced neutropenia are at particularly high risk, and microbiological agents include viral, bacterial and fungal agents. The etiology is often unknown in infectious complications, although adequate patient ev...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
AbstractWe performed a prospective multi-centre observational study to understand the incidence of IFI in patients with AML in India with use of anti-fungal prophylaxis. All patients with AML receiving either induction chemotherapy or salvage chemotherapy between November 2014 and February 2016 were included in this prospective observational study from 10 Indian centres. IFI was defined as per the revised EORTC-MSG criteria. Data on type of chemotherapy used, type of anti-fungal prophylaxis used, time to neutrophil recovery, incidence of IFI and survival were collected. Two hundred patients (118 male and 82 females) with a...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
Case: A 71-year-old male with acute myeloid leukemia (AML) on posaconazole for invasive fungal disease prophylaxis was found to have necrotic, escharred skin lesions on his bilateral forearms that developed while awaiting resolution of chemotherapy-induced neutropenia. 4-mm punch biopsies were performed through the necrotic center of each lesion and frozen sections were sent for investigation. Right forearm skin biopsy and frozen section were positive for angioinvasive fungal infection within the dermis and subcutis, which demonstrated vascular occlusion by numerous fungal hyphae.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
AbstractPatients with hematological malignancies are severely immunocompromised and are at high risk of invasive fungal infection (IFI), particularly those undergoing remission-induction chemotherapy for acute myeloid leukemia (AML). IFIs are a major cause of morbidity and mortality in such patients. We planned to study the incidence of IFI in patients with AML undergoing intensive chemotherapy and receiving antifungal prophylaxis. We retrospectively reviewed consecutive 46 patients with non-M3 AML, who received induction chemotherapy and systemic antifungal prophylaxis. None of the patients had IFI at the time of initiati...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
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