Nuclear ‐mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog‐1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer

AbstractLiver receptor homolog ‐1 (LRH‐1, NR5A2) is an orphan nuclear receptor with widespread activities in the regulation of development, stemness, metabolism, steroidogenesis, and proliferation. Many of the LRH‐1‐regulated processes target the mitochondria and associated activities. While under physiological conditions , a balanced LRH‐1 expression and regulation contribute to the maintenance of a physiological equilibrium, deregulation of LRH‐1 has been associated with inflammation and cancer. In this review, we discuss the role and mechanism(s) of how LRH‐1 regulates metabolic processes, cell survival, and cancer in a nuclear‐mitochondrial crosstalk, and evaluate its potential as a pharmacological target.
Source: IUBMB Life - Category: Research Authors: Tags: CRITICAL REVIEW Source Type: research