Striated preferentially expressed protein kinase (SPEG)-deficient skeletal muscles display fewer satellite cells with reduced proliferation and delayed differentiation.

In this study, we examined the overall population, proliferation, and differentiation of myogenic cells obtained from striated-muscle specific Speg-KO mice and compared them with wild-type (WT) controls. SPEG-deficient skeletal muscles contained fewer myogenic cells, which on further study demonstrated reduced proliferation and delayed differentiation compared to those from WT. Regenerative response to skeletal muscle injury in Speg-KO was compared to that of WT, leading to the identification of similar abnormalities including fewer satellite cells, fewer dividing cells, and an increase in apoptotic cells in KO mice. Overall, these results reveal specific abnormalities in myogenic cell number and behavior associated with SPEG deficiency. Similar SC defects have been reported in mouse models of MTM1- and DNM2-associated CNM, suggestive of shared underlying pathways. PMID: 32919980 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32919980?dopt=Abstract

Source: The American Journal of Pathology - September 9, 2020 Category: Pathology Authors: Li Q, Lin J, Rosen SM, Zhang T, Kazerounian S, Luo S, Agrawal PB Tags: Am J Pathol Source Type: research