Induction of regulatory T cells in L. major-infected BALB/c mice does not require Langerin+ dendritic cells

Cutaneous leishmaniasis is a disease caused by the protozoan parasite Leishmania major (L. major) and transferred to humans by infected phlebotomine sand flies. Cutaneous leishmaniasis manifests in lesion formation of the infected skin and poses a severe health burden with 1 million cases reported in the last five years. In healthy individuals and murine experimental leishmaniasis of resistant C57BL/6 mice, cutaneous disease can be controlled via Th1/Tc1-mediated immune responses that are characterized by IFN γ-driven macrophage activation and parasite killing, which induces live-long memory and protection.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research