Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

We have recently read the article by Feby Savira concerning “Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome” [1]. It indicated that inhibition of apoptosis signal-regulating kinase 1 (ASK1) attenuated left ventricular dysfunction and d iminished cardiac hypertrophy and cardiorenal fibrosis in a rat model of cardiorenal syndrome. The ASK1 inhibitor, GSK2261818A (G226), could be beneficial in the neurodegenerative disorders and inflammatory diseases, owing to its regulatory effect on stress-activated mitogen-activated protein kinase (MAP3K) family [2].

Source: International Journal of Cardiology - September 9, 2020 Category: Cardiology Authors: Wen-Ying Wei, Zhe-Xun Lian, Ji Yang, Ning Zhang Tags: Letter to the Editor Source Type: research