Glucocorticoid receptor gene polymorphisms in Guillain-Barr é syndrome

Guillain-Barr é syndrome (GBS) is an immune-mediated paralytic disorder. Glucocorticoid receptor (GR) gene polymorphisms affect the sensitivity to glucocorticoids and have been related to microbial colonization and infection, and thereby may influence susceptibility to GBS. The associations between GR polymorphi sms (ER22/23EK, N363S, BclI, TthIII-1and GR-9beta) and development of GBS were investigated in 151 patients and 151 healthy controls. GR polymorphisms or haplotypes were not associated with GBS susceptibility.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research