High extracellular phosphate increases platelet polyphosphate content.

High extracellular phosphate increases platelet polyphosphate content. Platelets. 2020 Sep 06;:1-3 Authors: Abbasian N, Harper MT Abstract Platelet-derived extracellular polyphosphate (PolyP) is a major mediator of thrombosis. PolyP is a linear chain of inorganic phosphate (P i ) and is stored in platelet dense granules. P i enters cells from the extracellular fluid through phosphate transporters and may be stored as PolyP. Here we show that high extracellular P i concentration in vitro increases platelet PolyP content, in a manner dependent on phosphate transporters, IP6K and V-type ATPases. The increased PolyP also enhanced PolyP-dependent coagulation in platelet-rich plasma. These data suggest a mechanistic link between hyperphosphatemia, PolyP and enhanced coagulation, which may be important in pathologies such as chronic kidney disease. PMID: 32892685 [PubMed - as supplied by publisher]
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research