Long non-coding RNAs as new players in cervical carcinogenesis: an update.

Long non-coding RNAs as new players in cervical carcinogenesis: an update. Eur Rev Med Pharmacol Sci. 2020 Aug;24(16):8314-8328 Authors: Salmerón-Bárcenas EG, Mendoza-Catalán MA, Illades-Aguiar B, Peralta-Arrieta I, Alquisiras-Burgos I, Ortiz-Ortiz J, Navarro-Tito N, Zacapala-Gómez AE Abstract Cervical cancer (CC) is the fourth most common cancer in women worldwide. Therefore, it is very important to understand cervical carcinogenesis, as well as the molecular mechanisms and signaling pathways involved in this process, in order to develop new strategies that contribute to diagnosis, prognosis and treatment of cervical cancer. Infection by high risk-human papillomavirus (HR-HPV) is a key event in cervical carcinogenesis, as well as, other factors, such as sociodemographics, lifestyle, sexual behavior, etc. In recent years, it has been shown that long non-coding RNA (lncRNA) are involved in CC and can be classified into tumor promoters or suppressors. Currently, several studies have analyzed the molecular mechanisms of some lncRNA in CC that might be acting, such as 1) competing endogenous RNAs (ceRNAs), 2) activators of signaling pathways, and 3) transcriptional regulators of genes. In this review, we summarized the more recent information on lncRNA and their role in the development of CC. PMID: 32894538 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research