Association of anti-NR2 and U1RNP antibodies with neurotoxic inflammatory mediators in cerebrospinal fluid from patients with neuropsychiatric systemic lupus erythematosus.

CONCLUSIONS: CSF anti-NR2 and anti-U1RNP Abs have different effects on the elevation of CSF IM levels in patients with NPSLE. Additional effect of anti-U1RNP Abs on anti-NR2 Ab-mediated NP manifestation, however, was not recognized in our study.
PMID: 32883159 [PubMed - as supplied by publisher]

Source: Lupus - September 2, 2020 Category: Rheumatology Authors: Kondo-Ishikawa S, Fujii T, Ishigooka N, Murakami K, Nakashima R, Hashimoto M, Yoshifuji H, Tanaka M, Ohmura K, Mimori T Tags: Lupus Source Type: research