Multifaceted Benefit of Whole Blood Versus Lactated Ringer ’s Resuscitation After Traumatic Brain Injury and Hemorrhagic Shock in Mice

ConclusionWB resuscitation after TBI  + HS results in robust improvements in brain oxygenation while minimizing fluid volume when compared to standard LR resuscitation. WB resuscitation may allow for a lower prehospital MAP without compromising brain oxygenation when compared to LR resuscitation. Further studies evaluating the effe cts of these physiologic benefits on outcome after TBI with HS are warranted, to eventually inform clinical trials.
Source: Neurocritical Care - Category: Neurology Source Type: research