Copy number alteration burden differentially impacts immune profiles and molecular features of hepatocellular carcinoma.

CONCLUSIONS: HCCs with high chromosomal instability exhibit features of immune exclusion, whereas tumors displaying low burdens of broad CNAs present an immune active profile. These CNA scores can be tested to predict response to immunotherapies.
PMID: 32873569 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - August 31, 2020 Category: Cancer & Oncology Authors: Bassaganyas L, Pinyol R, Esteban-Fabró R, Torrens L, Torrecilla S, Willoughby CE, Franch-Expósito S, Vila-Casadesús M, Salaverria I, Montal R, Mazzaferro V, Camps J, Sia D, Llovet JM Tags: Clin Cancer Res Source Type: research