Intravoxel incoherent motion diffusion-weighted MRI for the  characterization of inflammation in chronic liver disease

ConclusionPerfusion fractionf strongly correlated,D very weakly correlated, andD* weakly correlated with inflammation. Among all IVIM parameters,f accurately graded inflammation and showed promise as a biomarker of hepatic inflammation.Key Points•IVIM parameters derived from DWI series with 10 b-values are reproducible for liver tissue characterization.•This retrospective two-center study showed that perfusion fraction provided good diagnostic performance for distinguishing dichotomized grades of inflammation.•Fibrosis is a significant confounder on the association between inflammation and perfusion fraction.
Source: European Radiology - Category: Radiology Source Type: research