Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease

Coronary artery disease (CAD) arises from the interaction of genetic and environmental factors. Although genome-wide association studies (GWAS) have identified multiple risk loci and single nucleotide polymorphisms (SNPs) associated with risk of CAD, they are predominantly located in non-coding or intergenic regions and their mechanisms of effect are largely unknown. Accordingly, our objective was to develop a data-driven informatics pipeline to understand complex CAD risk loci, and to apply this to a poorly understood cluster of SNPs in the vicinity of ZEB2.

Source: Atherosclerosis - August 28, 2020 Category: Cardiology Authors: Lijiang Ma, Nirupama Chandel, Raili Ermel, Katyayani Sukhavasi, Ke Hao, Arno Ruusalepp, Johan L.M. Bj örkegren, Jason C. Kovacic Source Type: research