Nup133 and ER α mediate the differential effects of hyperoxia-induced damage in male and female OPCs

ConclusionsThese findings from a basic cell culture model establish prominent sex-based differences and suggest a novel mechanism involved in the differential response of OPCs towards oxidative stress. It conveys a strong message supporting the need to study how complex cellular processes are regulated differently in male and female brains during development and for a better understanding of how the brain copes up with different forms of stress after preterm birth.
Source: Molecular and Cellular Pediatrics - Category: Cytology Source Type: research