The effect of acute maximal exercise on the regional distribution of ventilation using ventilation MRI in CF

Exercise is increasingly recognised as an important component of disease management in cystic fibrosis (CF) [1]. Aerobic capacity, in particular the amount of oxygen uptake during maximal exercise (VO2peak), is highly predictive of long-term morbidity and mortality [2 –4]. VO2peak and other metrics calculated from lab-based cardio-pulmonary exercise testing (CPET) such as the ventilatory equivalents for O2 and CO2 (Ve/VO2 and Ve/VCO2 respectively), are strong predictors of hospitalisation [5], death and lung transplantation [4].

Source: Journal of Cystic Fibrosis - August 15, 2020 Category: Respiratory Medicine Authors: Laurie J. Smith, Helen Marshall, Jody Bray, Martin Wildman, Noreen West, Alex Horsley, Jim M. Wild Source Type: research