Moxifloxacin versus amoxicillin plus metronidazole as adjunctive therapy for generalized aggressive periodontitis: a pilot randomized controlled clinical trial

Ardila, Carlos M. / Fl órez-Flórez, Juliana / Castañeda-Parra, Luis-David / Guzmán, Isabel C. / Bedoya-García, Jader A.Page 612 - 621Objective: Adjunctive antimicrobials improve probing depth and clinical attachment loss compared with subgingival debridement (SD) alone in patients with aggressive periodontitis. The microbiologic and clinical effectiveness of moxifloxacin (MOX) and amoxicillin plus metronidazole (AMOX+ME) as adjunctive therapies for generalized aggressive periodontitis were compared.Method and materials: This pilot randomized controlled clinical trial included 36 patients who were assigned to one of three therapy groups: SD plus systemic MOX (400 mg QD for 7 days), SD plus systemic AMOX+ME (500 mg TID each for 7 days), or SD plus placebo. Probing depth, clinical attachment loss, bleeding on probing, and plaque were recorded at baseline and 3 and 6 months after treatment. Subgingival plaque samples were analyzed.Results: All treatments resulted in significant probing depth and clinical attachment loss reduction compared with the baseline values (P
Source: Quintessence International - Category: Dentistry Source Type: research