EP News: Allied Professionals

The authors (Lopez-Sainz et al. J Am Coll Cardiol 2020;76:186-97. PMID: 32646569) used data on patients from 27 European centers who have a variant of PRKAG2 gene to assess the clinical features and natural history of this abnormality. Previously, there were only reports with small numbers of patients with gene variants in PRKAG2 which causes a syndrome (PS) characterized by conduction disease, ventricular pre-excitation and hypertrophic cardiomyopathy (HCM). By pooling date from the 27 centers, 90 patients with a variant in PRKAG2 who were grouped as either affected (N=64) or unaffected (N=26) based on whether they had at least one of the following at the time of initial evaluation: unexplained left ventricular hypertrophy (LVH), left ventricular ejection fraction (LVEF)
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research