Perturbation of the circadian clock and pathogenesis of NAFLD

All living organisms including humans, experience changes in the light exposure generated by the Earth's rotation. In anticipation of this unavoidable geo-physical variability, and to generate an appropriate biochemical response, species of many phyla, including mammals have evolved a nearly 24-h endogenous timing device known as the circadian clock (CC), which is self-sustained, cell autonomous and is present in every cell type. At the heart of the ‘clock’ functioning resides the CC-oscillator, an elegantly designed transcriptional-translational feedback system.

Source: Metabolism - Clinical and Experimental - August 9, 2020 Category: Biomedical Science Authors: Atish Mukherji, Mayssa Dachraoui, Thomas F. Baumert Source Type: research