Hyperprolactinemia in Acromegaly is Related to Prolactin Secretion by Somatolactotroph Tumours

Horm Metab Res DOI: 10.1055/a-1207-1132The aim of this study is to assess differences in patient characteristics,
tumour characteristics and hormone levels between acromegalic patients with
and without hyperprolactinemia. 44 patients of the University Hospital of
Brussels, Belgium with acromegaly who were diagnosed between January 2007
and July 2018 were included in this study. Nineteen patients were classified
in the hyperprolactinemia group and 25 patients were classified in the
normoprolactinemia group. No significant differences between acromegalic
patients with and without hyperprolactinemia were found in age at diagnosis,
gender, presence of hyperprolactinemia symptoms, insulin-like growth factor
1, growth hormone and testosterone levels, tumour volume, tumour
invasiveness, immunohistochemistry of growth hormone and prolactin, Ki-67
index and mitotic index. However, for a cut-off of 10% of
prolactin-positive cells, there was a trend towards a higher percentage of
prolactin-positive tumours in hyperprolactinemia patients (p=0.054)
and higher mean prolactin level in case of positive prolactin immunostaining
(p=0.007)). In our study there were no differences in
characteristics between acromegaly patients with hyper- and
normoprolactinemia. An association between the serum ...

Source: Hormone and Metabolic Research - August 4, 2020 Category: Endocrinology Authors: Van Laethem, Delphine Michotte, Alex Cools, Wilfried Velkeniers, Brigitte Unuane, David Andreescu, C. E. Bravenboer, Bert Tags: Endocrine Care Source Type: research