Regulatory effects of Ningdong granule on microglia-mediated neuroinflammation in a rat model of Tourette's syndrome.

In conclusion, microglia might play key roles in mediating neuroinflammatory responses in TS, triggering the release of TNF-α, IL-6, and MCP-1.NDG inhibited tics in rats with TS, and this mechanism may be associated with a reduction in the increased number of activated microglia and a decrease in the expression of pro-inflammatory cytokines and chemokines in the striatum and/or serum. PMID: 32741856 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32741856?dopt=Abstract

Source: BioScience Trends - August 4, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research