Host antiviral protein IFITM2 restricts pseudorabies virus replication.

In this study, we show that IFITM is crucial for controlling PRV infection and that IFITM proteins can interfere with PRV cell binding and entry. Furthermore, we showed that IFITM2-mediated inhibition of PRV entry requires the cholesterol pathway. Collectively, these results provide insight into the anti-PRV role of IFITM proteins and this inhibition possible associated with the change of cholesterol in the endosome, further underlying the importance of cholesterol in virus infection.
PMID: 32745511 [PubMed - as supplied by publisher]

Source: Virus Research - July 30, 2020 Category: Virology Authors: Xie J, Bi Y, Xu S, Han Y, Idris A, Zhang H, Li X, Bai J, Zhang Y, Feng R Tags: Virus Res Source Type: research