Cell Cycle Dysregulation in Mantle Cell Lymphoma

This article reviews aberrations of cell cycle genes in MCL cells and clinical trials of CDK4/6 inhibitors for MCL. Integrative longitudinal functional genomics is discussed as a strategy to discover genomic drivers for resistance in cancer cells and cancer-immune interactions that potentially contribute to the clinical response to palbociclib combination therapy in MCL.

Source: Hematology/Oncology Clinics of North America - July 31, 2020 Category: Cancer & Oncology Authors: Kevin Wang, Xiangao Huang, Maurizio Di Liberto, Selina Chen-Kiang Source Type: research