Medical treatment can unintentionally alter the Treg compartment in patients with widespread pathophysiologic conditions

Regulatory T cells (Tregs) are non-redundant mediators of immune tolerance, critical to prevent autoimmune disease and promote an anti-inflammatory tissue environment. Many individuals experience diseases of a chronic nature and physiological changes associated with aging requiring long-term medication. Unfortunately, side-affects accompany every pharmacologic intervention and may impact overall outcomes. Here we focus on medications typically prescribed during the treatment of prevalent chronic diseases/disorders including cardiovascular disease, autoimmune disease, and menopausal symptoms affecting>200 million individuals in the US.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research