Dissociation in Pharmacokinetic Attenuation Between Central Dopamine D2 Receptor Occupancy and Peripheral Blood Concentration of Antipsychotics: A Systematic Review.

CONCLUSIONS: The findings indicate pharmacokinetic attenuation of antipsychotics was generally slower at the central versus the peripheral level and pose a critical challenge to the current dosing strategy that primarily relies on peripheral pharmacokinetics of antipsychotics. PMID: 32726002 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32726002?dopt=Abstract

Source: Journal of Clinical Psychiatry - July 31, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research